Top Definition
Verb. A side effect of extreme over indulgence in crystal meth or crack cocaine. Tweekers typically perform OCD-like activities centered around finding small quantities of drugs that were inadvertently "misplaced". Tweekers may be seen on all fours, searching in gutters, obsessively looking under various objects and so on. In certain circumstances, extreme tweeking resembles autism or catatonia.
Yo! Check out that tweeking crack ho!
מאת Slagathor 23 באפריל, 2004

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A character from the TV show "South Park". Tweek is the ADD kid, who is constantly twitching. He often rants and raves about things that only he sees, and is addicted to coffee. Tweek is in love with Craig, and they sex each other.
Wow. Tweek sure has sex with Craig a lot. It's hot.
מאת The Lord Of Spam 16 בפברואר, 2006

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losing oneself in a senseless task while under the influence of speed.
She would tweek all night cleaning the house and pulling apart electronic devices.
מאת chillcat 29 במאי, 2003

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the nervous ticks or twitching one experiances as they come down from a crystal methamphetamine binge.
pulling hairs out of their face; picking at their face; picking their nose...
מאת a former tweeker 28 בנובמבר, 2003

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Upper, crystal meth
can I have a bump of tweek?
מאת Cosmo Wash.DC 26 בדצמבר, 2002

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to adjust or fix
Let me just tweek your computer.
מאת Tracy Lukeman 20 באוקטובר, 2003

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To be high and see something that is not not present.
I was driving around I started tweeking , I thought I seen someone on the road
מאת URBAN HOODS 19 בינואר, 2015

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