Mary, the mother of Jesus. This is typically an exclamation of disbelief, usually targeted at something so out there that it's hard to believe or process. You could also say "Holy shit!" -- it's quicker.
Sweet mother of Jesus! Did you see that chick just crush those beer cans with her 44HHH tits?!?!
מאת toxicsky 8 בפברואר, 2010