Gurlfran originally comes from girlfriend
, specifically aiming at girls that are friends of girls. Popular in African American and gay community.
You're best friend. That bitch you hate in second period French. Jesus.
Gurlfran can be used in place of girlfriend, dude, ese, way, nigga, and/or bitch.
AYYYYYYYY GURLFRAN WHAT IT DO? U AINT GONNA BULEAF DIS SHIT, GURL.